Editing Ketamine (section)

=== Brain damage ===
Despite the balance of palliative benefits  which planned course(s) of therapy can confer when patients face serious medical conditions, ongoing ketamine use is known to cause
brain damage including reduction in both white and grey matter seen on MRI imaging and atrophy seen on CT scans.<ref>{{cite journal|date= October 2021 |title=Severe Encephalatrophy and Related Disorders From Long-Term Ketamine Abuse: A Case Report and Literature Review |publisher= National Institute of Health |pmc=8519172 |journal=Frontiers in Psychiatry |volume=12 |doi=10.3389/fpsyt.2021.707326 |doi-access=free |pmid=34658951 | vauthors = Liu L, Huang H, Li Y, Zhang R, Wei Y, Wu W }}</ref> Destruction of dendrite trees is a consideration even with repeated low doses.<ref>{{cite journal|date= May 2007 |title= Low concentrations of ketamine initiate dendritic atrophy of differentiated GABAergic neurons in culture|url=https://www.sciencedirect.com/science/article/abs/pii/S0300483X07001138 |journal=Toxicology |doi= 10.1016/j.tox.2007.03.004|access-date=May 2025|volume= 234|issue= 3|pages= 216–226|pmid= 17418473|bibcode= 2007Toxgy.234..216V| vauthors = Vutskits L, Gascon E, Potter G, Tassonyi E, Kiss JZ }}</ref>  Cognitive deficits as well as increased dissociation and [[delusion]]s were observed in frequent recreational users of ketamine.<ref name="Morgan2009">{{cite journal |vauthors=Morgan CJ, Muetzelfeldt L, Curran HV |title=Consequences of chronic ketamine self-administration upon neurocognitive function and psychological wellbeing: a 1-year longitudinal study |journal=Addiction |volume=105 |issue=1 |pages=121–33 |date=January 2010 |pmid=19919593 |doi=10.1111/j.1360-0443.2009.02761.x}}</ref>