Editing Jet lag (section)

=== Chronic inflammation ===
Recent studies have demonstrated the delicate balance that circadian rhythm provides towards gut-microbiome. Chronic circadian rhythm disruption introduces a variety of disturbances within the gut that can potentially cause a multitude of issues such as inflammation. This is due to, what researchers call, a misalignment of regulatory clocks that control metabolic processes that spike [[insulin]] levels when there's an irregular timing of food intake causing inflammation.<ref>{{cite journal |last1=Crespo |first1=Manuel Tomás |last2=Trebucq |first2=Laura Lucía |last3=Senna |first3=Camila Agustina |last4=Hokama |first4=Guido |last5=Paladino |first5=Natalia |last6=Agostino |first6=Patricia Verónica |last7=Chiesa |first7=Juan José |title=Circadian disruption of feeding-fasting rhythm and its consequences for metabolic, immune, cancer, and cognitive processes |journal=Biomedical Journal |date=January 2025 |pages=100827 |doi=10.1016/j.bj.2025.100827 |pmid=39756653 |doi-access=free }}</ref> Researchers have longed believed in the correlation of proper circadian balance, the disruption of the balance and its side effects, and metabolism though more research is needed to understand underlying mechanisms.<ref>{{cite journal |last1=Woller |first1=Aurore |last2=Gonze |first2=Didier |title=Circadian Misalignment and Metabolic Disorders: A Story of Twisted Clocks |journal=Biology |date=10 March 2021 |volume=10 |issue=3 |pages=207 |doi=10.3390/biology10030207 |doi-access=free |pmc=8001388 |pmid=33801795 }}</ref>