Editing Hemolysis (section)

===Intravascular hemolysis===
{{main|Intravascular hemolysis}}

'''Intravascular hemolysis''' describes hemolysis that happens mainly inside the [[vasculature]].<ref name="Stanley 2018">{{cite web | title=Diagnosis of hemolytic anemia in the adult | website=UpToDate | url=https://www.uptodate.com/contents/diagnosis-of-hemolytic-anemia-in-the-adult | access-date=2019-05-04 | author=Stanley L Schrier | editor1=William C Mentzer | editor2=Jennifer S Tirnauer | archive-url=https://web.archive.org/web/20171226181455/http://www.uptodate.com/contents/diagnosis-of-hemolytic-anemia-in-the-adult | archive-date=2017-12-26 | url-status=dead }}</ref> As a result, the contents of the red blood cell are released into the general circulation, leading to [[hemoglobinemia]]<ref name="eClinpath Intravascular hemolysis">{{cite web|url=http://eclinpath.com/hematology/anemia/mechanisms-of-anemia/intravascular-hemolysis-new/|title=Intravascular hemolysis|website=eClinpath|access-date=2019-05-08}}</ref> and increasing the risk of ensuing [[hyperbilirubinemia]].<ref name="Muller Jacobsen Healy McMickan 2006 pp. 229–241">{{cite journal | last1=Muller | first1=Andre | last2=Jacobsen | first2=Helene | last3=Healy | first3=Edel | last4=McMickan | first4=Sinead | last5=Istace | first5=Fréderique | last6=Blaude | first6=Marie-Noëlle | last7=Howden | first7=Peter | last8=Fleig | first8=Helmut | last9=Schulte | first9=Agnes | title=Hazard classification of chemicals inducing haemolytic anaemia: An EU regulatory perspective | journal=Regulatory Toxicology and Pharmacology | publisher=Elsevier BV | volume=45 | issue=3 | year=2006 | issn=0273-2300 | doi=10.1016/j.yrtph.2006.04.004 | pmid=16793184 | pages=229–241 | url=https://rivm.openrepository.com/bitstream/handle/10029/5596/muller.pdf?sequence=1&isAllowed=y | archive-url=https://web.archive.org/web/20190503184457/https://rivm.openrepository.com/bitstream/handle/10029/5596/muller.pdf?sequence=1&isAllowed=y | url-status=dead | archive-date=2019-05-03 | access-date=2019-05-04| hdl=10029/5596 | hdl-access=free }}</ref>

Intravascular hemolysis may occur when red blood cells are targeted by [[Autoantibody|autoantibodies]], leading to [[Complement system|complement]] fixation, or by damage by parasites such as ''[[Babesia]]''.<ref name="eClinpath Bilirubin and hemolytic anemia">{{cite web | title=Bilirubin and hemolytic anemia | website=eClinpath | url=http://eclinpath.com/chemistry/liver/cholestasis/bilirubin/bilirubin-and-hemolysis/ | access-date=2019-05-08}}</ref> Additionally, thrombotic microangiopathy (TMA) can result in hemolysis of red blood cells.<ref>{{Cite web|title=Thrombotic Microangiopathy (TMA)|url=https://unckidneycenter.org/kidneyhealthlibrary/glomerular-disease/thrombotic-microangiopathy-tma/|access-date=2020-08-19|website=UNC Kidney Center|language=en-US}}</ref> TMA is frequently observed in [[Atypical hemolytic uremic syndrome|aHUS]] patients where clots form in the small vessels of the kidney resulting in damaged red blood cells as they attempt to pass through the restricted vessels.<ref>{{Cite web|title=Atypical Hemolytic Uremic Syndrome|url=https://rarediseases.org/rare-diseases/atypical-hemolytic-uremic-syndrome/|access-date=2020-08-19|website=NORD (National Organization for Rare Disorders)|language=en-US}}</ref>