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===Somatic effects=== Cannabis use can decrease [[blood pressure]], which increases the risk of [[syncope (medicine)|fainting]].<ref>{{Cite web |last=Canada |first=Health |date=2018-03-02 |title=Health effects of cannabis |url=https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/health-effects/effects.html |url-status=live |archive-url=https://web.archive.org/web/20221117173810/https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/health-effects/effects.html |archive-date=17 November 2022 |access-date=2022-11-17 |website=www.canada.ca}}</ref> Combining alcohol with cannabis greatly increases the level of impairment and the risk of injury or death from accidents.<ref>{{Cite web |title=Health effects of cannabis |url=https://www.canada.ca/content/dam/hc-sc/documents/services/campaigns/27-16-1808-Factsheet-Health-Effects-eng-web.pdf |url-status=live |archive-url=https://web.archive.org/web/20221117173817/https://www.canada.ca/content/dam/hc-sc/documents/services/campaigns/27-16-1808-Factsheet-Health-Effects-eng-web.pdf |archive-date=17 November 2022 |access-date=17 November 2022}}</ref>[[File:Bloodshot EyeBall.jpg|thumb|right|Bloodshot eye]] Some of the short-term physical effects of cannabis use include increased [[heart rate]], [[xerostomia|dry mouth]], reddening of the eyes (congestion of the [[conjunctiva]]l [[blood vessel]]s), a reduction in [[intra-ocular pressure]], muscle relaxation, and a sensation of cold or hot hands and feet.<ref>{{cite web |url=http://web4health.info/en/answers/add-cannabis-physical.htm |title=How does Marijuana Affect Your Body? What are the Marijuana Physical Effects? |first=Wendy |last=Moelker |name-list-style=vanc |date=19 September 2008 |access-date=22 January 2009 |archive-date=7 February 2009 |archive-url=https://web.archive.org/web/20090207012048/http://web4health.info/en/answers/add-cannabis-physical.htm |url-status=live }}</ref> [[Electroencephalography]] (EEG) shows somewhat more persistent [[alpha wave]]s of slightly lower [[frequency]] than usual.<ref name=autogenerated2>{{cite book| title=Principles of Medical Pharmacology | edition=6th |author1=Kalant, H.K. |author2=Roschlau, W.H.E. | year=1998 | pages=373β375}}</ref> Cannabinoids produce a marked depression of motor activity via activation of receptors of [[cannabinoid receptor type 1]].<ref>{{cite journal | vauthors = Andersson M, Usiello A, Borgkvist A, Pozzi L, Dominguez C, Fienberg AA, Svenningsson P, Fredholm BB, Borrelli E, Greengard P, Fisone G | title = Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons | journal = The Journal of Neuroscience | volume = 25 | issue = 37 | pages = 8432β8 | date = September 2005 | pmid = 16162925 | pmc = 6725667 | doi = 10.1523/JNEUROSCI.1289-05.2005 }}</ref>
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