Editing Down syndrome (section)

===Gastrointestinal===
[[Constipation]] occurs in nearly half of people with Down syndrome and may result in changes in behavior.<ref name=Hick2012/> One potential cause is [[Hirschsprung's disease]], occurring in 2–15%, which is due to a lack of [[Neuron|nerve cells]] controlling the [[colon (anatomy)|colon]].<ref>{{cite journal | vauthors = Moore SW | title = Down syndrome and the enteric nervous system | journal = Pediatric Surgery International | volume = 24 | issue = 8 | pages = 873–883 | date = August 2008 | pmid = 18633623 | doi = 10.1007/s00383-008-2188-7 | s2cid = 11890549 }}</ref> Other congenital problems can include [[duodenal atresia]], [[imperforate anus]] and [[gastroesophageal reflux disease]].<ref name=Tint2010/> [[Celiac disease]] affects about 7–20%.<ref name="Malt2013" /><ref name="Hick2012" />