Editing Dendritic cell (section)

=== Blastic plasmacytoid dendritic cell neoplasm ===
Blastic plasmacytoid dendritic cell neoplasm is a rare type of [[myeloid]] cancer in which malignant pDCs infiltrate the skin, bone marrow, central nervous system, and other tissues. Typically, the disease presents with skin lesions (e.g. nodules, tumors, [[papule]]s, bruise-like patches, and/or ulcers) that most often occur on the head, face, and upper torso.<ref name="pmid29760611">{{cite journal | vauthors = Owczarczyk-Saczonek A, Sokołowska-Wojdyło M, Olszewska B, Malek M, Znajewska-Pander A, Kowalczyk A, Biernat W, Poniatowska-Broniek G, Knopińska-Posłuszny W, Kozielec Z, Nowicki R, Placek W | title = Clinicopathologic retrospective analysis of blastic plasmacytoid dendritic cell neoplasms | journal = Postepy Dermatologii I Alergologii | volume = 35 | issue = 2 | pages = 128–138 | date = April 2018 | pmid = 29760611 | pmc = 5949541 | doi = 10.5114/ada.2017.72269 }}</ref> This presentation may be accompanied by cPC infiltrations into other tissues to result in swollen [[lymph node]]s, enlarged liver, enlarged spleen, symptoms of [[central nervous system]] dysfunction, and similar abnormalities in breasts, eyes, kidneys, lungs, gastrointestinal tract, bone, sinuses, ears, and/or testes.<ref name="pmid28906324"/> The disease may also present as a pDC [[leukemia]], i.e. increased levels of malignant pDC in blood (i.e. >2% of nucleated cells) and bone marrow and evidence (i.e. [[cytopenia]]s) of [[bone marrow failure]].<ref name="pmid28906324">{{cite journal | vauthors = Kim MJ, Nasr A, Kabir B, de Nanassy J, Tang K, Menzies-Toman D, Johnston D, El Demellawy D | title = Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm: A Systematic Literature Review | journal = Journal of Pediatric Hematology/Oncology | volume = 39 | issue = 7 | pages = 528–537 | date = October 2017 | pmid = 28906324 | doi = 10.1097/MPH.0000000000000964 | s2cid = 11799428 }}</ref> Blastic plasmacytoid dendritic cell neoplasm has a high rate of recurrence following initial treatments with various [[chemotherapy]] regimens. In consequence, the disease has a poor overall prognosis and newer [[Blastic plasmacytoid dendritic cell neoplasm#Treatment|chemotherapeutic]] and novel [[Blastic plasmacytoid dendritic cell neoplasm#Novel treatments|non-chemotherapeutic drug]] regimens to improve the situation are under study.<ref name="pmid29455234">{{cite journal | vauthors = Wang S, Wang X, Liu M, Bai O | title = Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel agents | journal = Annals of Hematology | volume = 97 | issue = 4 | pages = 563–572 | date = April 2018 | pmid = 29455234 | doi = 10.1007/s00277-018-3259-z | s2cid = 3627886 }}</ref>