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===Necessity of ipRGCs=== Mice without (Opn4<sup>aDTA/aDTA</sup> mice) are not susceptible to the negative effects of an aberrant light cycle, indicating that light information transmitted through these cells plays an important role in regulation of mood and cognitive functions such as learning and memory.<ref name=Monteggia>{{cite journal|last1=Monteggia|first1=Lisa|author-link1=Lisa Monteggia|last2=Kavalali|first2=E. T.|title=Circadian rhythms: Depression brought to light|journal=Nature|volume=491|issue=7425|pages=537β538|doi=10.1038/nature11752|pmid=23151474|year=2012|bibcode=2012Natur.491..537M|s2cid=4391543}}</ref>
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