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==== Diabetes mellitus ==== Epinephrine signals early warning of the upcoming [[hypoglycemia]].<ref name="Sprague Arbeláez 2011 pp. 463–475">{{cite journal | vauthors = Sprague JE, Arbeláez AM | title = Glucose counterregulatory responses to hypoglycemia | journal = Pediatric Endocrinology Reviews | volume = 9 | issue = 1 | pages = 463–475 | date = September 2011 | pmid = 22783644 | pmc = 3755377 }}</ref> Beta blockers' inhibition on epinephrine's effect can somewhat exacerbate hypoglycemia by interfering with [[glycogenolysis]] and mask signs of hypoglycemia such as tachycardia, palpitations, [[diaphoresis]], and tremors. Diligent blood glucose level monitoring is necessary for a patient with diabetes mellitus on beta blockers.
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