Editing Benign prostatic hyperplasia (section)

==== Medications ====
Certain medications can increase urination difficulties by increasing bladder outlet resistance due to increased [[smooth muscle]] tone at the prostate or bladder neck and contribute to LUTS.<ref name="Kim2016" /> [[Alpha-adrenergic agonist]] medications, such as [[decongestant]]s with [[pseudoephedrine]] can increase bladder outlet resistance.<ref name="Kim2016" /> In contrast, [[calcium channel blocker]]s and [[anticholinergic]] medications can worsen urinary retention by promoting bladder muscle relaxation.<ref name="Kim2016" /> Diuretic medications such as [[loop diuretic]]s (e.g., [[furosemide]]) or [[thiazide]]s (e.g., [[chlorthalidone]]) can cause or worsen urinary frequency and nighttime awakenings to urinate.<ref name="Kim2016" />

<gallery class="center">
File:Nodular hyperplasia of the prostate.jpg|[[Micrograph]] showing nodular hyperplasia (left off center) of the prostate from a [[transurethral resection of the prostate]] (TURP). [[H&E stain]].
File:Prostate histology.jpg|Microscopic examination of different types of prostate tissues (stained with [[immunohistochemistry|immuno{{shy}}histochemical]] techniques): A. Normal (non-neoplastic) prostatic tissue (NNT). B. Benign prostatic hyperplasia. C. [[High-grade prostatic intraepithelial neoplasia]]. D. [[Prostatic adenocarcinoma]] (PCA).
</gallery>