Editing Autosomal dominant polycystic kidney disease (section)

===Nephrectomy===
Many ADPKD patients experience symptomatic sequelae in consequence of the disease, such as cyst [[hemorrhage]], [[flank pain]], recurrent [[infection]]s, [[nephrolithiasis]], and symptoms of mass effect (i.e., early [[satiety]], [[nausea]] and vomiting, and abdominal discomfort), from their enlarged kidneys.<ref name="TP-150518-E08">{{cite journal | vauthors = Alam A, Perrone RD | title = Management of ESRD in patients with autosomal dominant polycystic kidney disease | journal = Advances in Chronic Kidney Disease | volume = 17 | issue = 2 | pages = 164–172 | date = March 2010 | pmid = 20219619 | doi = 10.1053/j.ackd.2009.12.006 }}</ref><ref name="TP-150518-E09">{{cite journal | vauthors = Wagner MD, Prather JC, Barry JM | title = Selective, concurrent bilateral nephrectomies at renal transplantation for autosomal dominant polycystic kidney disease | journal = The Journal of Urology | volume = 177 | issue = 6 | pages = 2250–4; discussion 2254 | date = June 2007 | pmid = 17509331 | doi = 10.1016/j.juro.2007.01.146 }}</ref><ref name="TP-150518-E13">{{cite journal | vauthors = Cristea O, Yanko D, Felbel S, House A, Sener A, Luke PP | title = Maximal kidney length predicts need for native nephrectomy in ADPKD patients undergoing renal transplantation | journal = Canadian Urological Association Journal | volume = 8 | issue = 7–8 | pages = 278–282 | date = July 2014 | pmid = 25210553 | pmc = 4137014 | doi = 10.5489/cuaj.2128 }}</ref> In such cases, [[nephrectomy]] can be required due to intractable symptoms or when in the course of preparing for [[kidney transplantation]], the native kidneys are found to impinge upon the [[true pelvis]] and preclude the placement of a donor [[allograft]].<ref name="TP-150518-E09" /><ref name="TP-150518-E13" /><ref name="TP-150518-E10">{{cite journal | vauthors = Fuller TF, Brennan TV, Feng S, Kang SM, Stock PG, Freise CE | title = End stage polycystic kidney disease: indications and timing of native nephrectomy relative to kidney transplantation | journal = The Journal of Urology | volume = 174 | issue = 6 | pages = 2284–2288 | date = December 2005 | pmid = 16280813 | doi = 10.1097/01.ju.0000181208.06507.aa | s2cid = 25363382 }}</ref><ref name="TP-150518-E11">{{cite journal | vauthors = Cohen D, Timsit MO, Chrétien Y, Thiounn N, Vassiliu V, Mamzer MF, Legendre C, Méjean A | display-authors = 6 | title = [Place of nephrectomy in patients with autosomal dominant polycystic kidney disease waiting for renal transplantation] | journal = Progres en Urologie | volume = 18 | issue = 10 | pages = 642–649 | date = November 2008 | pmid = 18971106 | doi = 10.1016/j.purol.2008.06.004 }}</ref> Additionally, native nephrectomy may be undertaken in the presence of suspected malignancy, as renal cell carcinoma (RCC) is two to three times more likely in the ADPKD population in [[Kidney failure|end-stage kidney disease]] (ESKD) than in the ESKD patients without ADPKD.<ref name="TP-150518-E13" /><ref name="TP-150518-E12">{{cite journal | vauthors = Hajj P, Ferlicot S, Massoud W, Awad A, Hammoudi Y, Charpentier B, Durrbach A, Droupy S, Benoît G | display-authors = 6 | title = Prevalence of renal cell carcinoma in patients with autosomal dominant polycystic kidney disease and chronic renal failure | journal = Urology | volume = 74 | issue = 3 | pages = 631–634 | date = September 2009 | pmid = 19616833 | doi = 10.1016/j.urology.2009.02.078 }}</ref> Although the indications for nephrectomy in ADPKD may be related to kidney size, the decision to proceed with native nephrectomy is often undertaken on an individual basis, without specific reference to kidney size measurements.<ref name="TP-150518-E13" />