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===Adrenal insufficiency=== Treatment of the adrenal insufficiency that can accompany any of the common male phenotypes of ALD does not resolve any of the neurological symptoms. Hormone replacement is standard for ALD patients demonstrating adrenal insufficiency.<ref name=peroxleuk>{{cite journal |last1=Poll-The |first1=Bwee |last2=Engelen |first2=Marc |title=Peroxisomal Leukoencephalopathy |journal=Seminars in Neurology |date=15 March 2012 |volume=32 |issue=1 |pages=042β050 |doi=10.1055/s-0032-1306385 |pmid=22422205 |s2cid=39152217 }}</ref> Adrenal insufficiency does not resolve with successful transplant; most patients still require hormone replacement.<ref name=adrenalfunction />
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