Editing Treponema pallidum (section)

===== TP0965 =====
TP0965 is a protein that is critical for membrane fusion in ''T. pallidum'', and is located in the [[periplasm]].<ref name="Chen22" /> TP0965 causes endothelial barrier dysfunction, a hallmark of late-stage pathogenesis of [[syphilis]].<ref>{{Cite journal |last1=McKevitt |first1=Matthew |last2=Brinkman |first2=Mary Beth |last3=McLoughlin |first3=Melanie |last4=Perez |first4=Carla |last5=Howell |first5=Jerrilyn K. |last6=Weinstock |first6=George M. |last7=Norris |first7=Steven J. |last8=Palzkill |first8=Timothy |date=July 2005 |title=Genome Scale Identification of ''Treponema pallidum'' Antigens |journal=Infection and Immunity |volume=73 |issue=7 |pages=4445–50 |doi=10.1128/iai.73.7.4445-4450.2005 |pmc=1168556 |pmid=15972547}}</ref> It does this by reducing the expression of tight junction proteins, which in turn increases the expression of adhesion molecules and endothelial cell permeability, which eventually leads to disruption of the [[Endothelium|endothelial]] layer.<ref>{{Cite journal |last1=Zhang |first1=Rui-Li |last2=Zhang |first2=Jing-Ping |last3=Wang |first3=Qian-Qiu |date=16 December 2014 |title=Recombinant ''Treponema pallidum'' Protein Tp0965 Activates Endothelial Cells and Increases the Permeability of Endothelial Cell Monolayer |journal=PLOS ONE |volume=9 |issue=12 |pages=e115134 |bibcode=2014PLoSO...9k5134Z |doi=10.1371/journal.pone.0115134 |pmc=4267829 |pmid=25514584 |doi-access=free}}</ref>