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==Pathophysiology== Tinnitus may be caused by increased neural activity in the auditory brainstem, where the brain processes sounds, causing some auditory nerve cells to become overexcited. The basis of this theory is that many with tinnitus also have [[hearing loss]].<ref name="Nicolas-Puel">{{cite journal |pmid=14763234 |last1=Nicolas-Puel |first1=C |last2=Faulconbridge |first2=RL |last3=Guitton |first3=M |last4=Puel |first4=JL |last5=Mondain |first5=M |last6=Uziel |first6=A |title=Characteristics of tinnitus and etiology of associated hearing loss: a study of 123 patients |journal=The International Tinnitus Journal |volume=8 |issue=1 |year=2002 |pages=37β44}}</ref> Three reviews in 2016 emphasized the large range and possible combinations of pathologies involved in tinnitus, which result in a great variety of symptoms and specifically adapted therapies.<ref name="pmid26977153">{{cite journal | vauthors = MΓΈller AR | title = Sensorineural Tinnitus: Its Pathology and Probable Therapies | journal = International Journal of Otolaryngology | volume = 2016 | pages = 1β13 | year = 2016 | pmid = 26977153 | pmc = 4761664 | doi = 10.1155/2016/2830157 | doi-access = free }}</ref><ref name="pmid27871729">{{cite journal | vauthors = Sedley W, Friston KJ, Gander PE, Kumar S, Griffiths TD | title = An Integrative Tinnitus Model Based on Sensory Precision | journal = Trends in Neurosciences | volume = 39 | issue = 12 | pages = 799β812 | year = 2016 | pmid = 27871729 | pmc = 5152595 | doi = 10.1016/j.tins.2016.10.004 }}</ref><ref name="pmid26868680">{{cite journal | vauthors = Shore SE, Roberts LE, Langguth B | title = Maladaptive plasticity in tinnitus β triggers, mechanisms and treatment | journal = Nature Reviews Neurology | volume = 12 | issue = 3 | pages = 150β160 | year = 2016 | pmid = 26868680 | pmc = 4895692 | doi = 10.1038/nrneurol.2016.12 }}</ref><ref>{{cite journal |last1=Park |first1=Jung Mee |last2=Kim |first2=Woo Jin |last3=Han |first3=Jae Sang |last4=Park |first4=So Young |last5=Park |first5=Shi Nae |title=Management of palatal myoclonic tinnitus based on clinical characteristics: a large case series study |journal=Acta Oto-Laryngologica |date=2 July 2020 |volume=140 |issue=7 |pages=553β557 |doi=10.1080/00016489.2020.1749724 |pmid=32406274 |s2cid=218635840 }}</ref>
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