Editing Stem cell (section)

===Hematopoietic stem cells===

[[Hematopoietic stem cell]]s (HSCs) are vulnerable to [[DNA damage (naturally occurring)|DNA damage]] and [[mutation]]s that increase with age.<ref name="Zhang2020">Zhang L, Mack R, Breslin P, Zhang J. Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches. J Hematol Oncol. 2020 Nov 23;13(1):157. doi: 10.1186/s13045-020-00994-z. PMID 33228751; PMCID: PMC7686726</ref> This vulnerability may explain the increased risk of slow growing blood cancers (myeloid malignancies) in the elderly.<ref name = Zhang2020/>  Several factors appear to influence HSC aging including responses to the production of [[reactive oxygen species]] that may cause DNA damage and genetic mutations as well as altered [[epigenetics|epigenetic]] profiling.<ref>Montazersaheb S, Ehsani A, Fathi E, Farahzadi R. Cellular and Molecular Mechanisms Involved in Hematopoietic Stem Cell Aging as a Clinical Prospect. Oxid Med Cell Longev. 2022 Apr 1;2022:2713483. doi: 10.1155/2022/2713483. PMID 35401928; PMCID: PMC8993567</ref>