Editing Salvinorin A (section)

=== Chemical synthesis ===
A total [[asymmetric synthesis]] of salvinorin&nbsp;A, which relies on a transannular [[Michael reaction]] cascade to construct the ring system, was achieved as a 4.5% overall yield over 30 steps,<ref name=Scheerer2007/> then revised using 24 steps to yield salvinorin&nbsp;A in 0.15% yield.<ref name=Nozawa2008/> An approach to the ''trans''-decalin ring system of salvinorin&nbsp;A used an intramolecular [[Diels-Alder reaction]]/[[intramolecular Diels-Alder cycloaddition|Tsuji allylation]] strategy,<ref name=Burns2008/> and a total synthesis of salvinorin A was achieved using the intramolecular Diels-Alder / Tsuji allylation approach, combined with an asymmetric late-stage addition of the furan moiety.<ref>{{cite journal | vauthors = Line NJ, Burns AC, Butler SC, Casbohm J, Forsyth CJ | title = Total Synthesis of (-)-Salvinorin A | journal = Chemistry: A European Journal | volume = 22 | issue = 50 | pages = 17983–17986 | date = December 2016 | pmid = 27758012 | doi = 10.1002/chem.201604853 }}</ref>