Editing Peripheral membrane protein (section)

===Structural domains===
Structural domains mediate attachment of other proteins to membranes. Their binding to membranes can be mediated by [[calcium]] ions (Ca<sup>2+</sup>) that form bridges between the acidic protein residues and phosphate groups of lipids, as in annexins or GLA domains.

{| class="wikitable" style="margin: 1em auto 1em auto"
!width="150"|Class
!width="275"|Function
!width="305"| Physiology
!width="50"| Structure
|-
|[[Annexin]]s || [[Calcium]]-dependent intracellular membrane/ [[phospholipid]] binding.<ref>{{Cite web |url=http://www.sanger.ac.uk//cgi-bin/Pfam/getacc?PF00191 |title=Pfam entry: Annexin |access-date=2007-01-25 |archive-url=https://web.archive.org/web/20070929104531/http://www.sanger.ac.uk//cgi-bin/Pfam/getacc?PF00191 |archive-date=2007-09-29 |url-status=dead }}</ref> || Functions include [[Vesicle (biology)|vesicle]] trafficking, membrane fusion and [[ion channel]] formation.||
|-
|[[Synapsin|Synapsin I]]|| Coats [[synaptic vesicle]]s and binds to several [[cytoskeletal]] elements.<ref>{{Cite web |url=http://www.sanger.ac.uk//cgi-bin/Pfam/getacc?PF02078 |title=Pfam entry Synapsin N |access-date=2007-01-25 |archive-url=https://web.archive.org/web/20070926215343/http://www.sanger.ac.uk//cgi-bin/Pfam/getacc?PF02078 |archive-date=2007-09-26 |url-status=dead }}</ref>|| Functions in the regulation of [[neurotransmitter]] release.||
|-
|[[Synuclein]]|| Unknown cellular function.<ref>{{Cite web |url=http://www.sanger.ac.uk//cgi-bin/Pfam/getacc?PF01387 |title=Pfam entry Synuclein |access-date=2007-01-25 |archive-url=https://web.archive.org/web/20070926215944/http://www.sanger.ac.uk//cgi-bin/Pfam/getacc?PF01387 |archive-date=2007-09-26 |url-status=dead }}</ref>|| Thought to play a role in regulating the stability and/or turnover of the [[plasma membrane]]. Associated with both [[Parkinson's disease]] and [[Alzheimer's disease]].||
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|GLA-domains of the [[coagulation|coagulation system]]|| [[Gamma-carboxyglutamate]] (GLA) domains are responsible for the high-affinity binding of calcium ions.<ref>{{Cite web |url=http://www.sanger.ac.uk//cgi-bin/Pfam/getacc?PF00594 |title=Pfam entry: Gla |access-date=2007-01-25 |archive-url=https://web.archive.org/web/20070929111243/http://www.sanger.ac.uk//cgi-bin/Pfam/getacc?PF00594 |archive-date=2007-09-29 |url-status=dead }}</ref>|| Involved in function of clotting factors in the [[Coagulation#The coagulation cascade|blood coagulation cascade.]]||
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| [[Spectrin]] and α-[[actinin]]-2 || Found in several cytoskeletal and [[microfilament]] proteins.<ref>{{Cite web |url=http://www.sanger.ac.uk//cgi-bin/Pfam/getacc?PF00435 |title=Pfam entry Spectrin |access-date=2007-01-25 |archive-url=https://web.archive.org/web/20070926215853/http://www.sanger.ac.uk//cgi-bin/Pfam/getacc?PF00435 |archive-date=2007-09-26 |url-status=dead }}</ref> || Maintenance of [[plasma membrane]] integrity and cytoskeletal structure.||
|}