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==In plants== If calcium is deficient, [[pectin]] cannot be synthesized, and therefore the cell walls cannot be bonded and thus an impediment of the meristems. This will lead to necrosis of stem and root tips and leaf edges.<ref name=Capon_2010>{{cite book| author = Capon B | title = Botany for gardeners | date = 2010 | publisher = Timber Press | location = Portland, OR | isbn = 978-1-60469-095-8 | edition = 3rd |oclc=436623458}}</ref> For example, necrosis of tissue can occur in [[Arabidopsis thaliana#Evolutionary aspect of plant-pathogen resistance|''Arabidopsis thaliana'']] due to plant pathogens.<ref>{{cite journal |vauthors=Summermatter K, Sticher L, Metraux JP |title=Systemic Responses in Arabidopsis thaliana Infected and Challenged with Pseudomonas syringae pv syringae |journal=Plant Physiol |volume=108 |issue=4 |pages=1379β85 |date=August 1995 |pmid=12228548 |pmc=157515 |doi=10.1104/pp.108.4.1379 }}</ref> Cacti such as the Saguaro and Cardon in the Sonoran Desert experience necrotic patch formation regularly; a species of Dipterans called [[Drosophila mettleri|Drosophila ''mettleri'']] has developed a [[Cytochrome P450|P450]] detoxification system to enable it to use the exudates released in these patches to both nest and feed larvae.<ref>{{cite journal |vauthors=Giraudo M, Unnithan GC, Le Goff G, Feyereisen R |title=Regulation of cytochrome P450 expression in Drosophila: Genomic insights |journal=Pestic Biochem Physiol |volume=97 |issue=2 |pages=115β122 |date=June 2010 |pmid=20582327 |pmc=2890303 |doi=10.1016/j.pestbp.2009.06.009 }}</ref>
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