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== Aging == Unlike many other enzymes, MAO-B activity is increased during aging in the brain of humans and other mammals.<ref>{{cite journal | vauthors = Nicotra A, Pierucci F, Parvez H, Senatori O | title = Monoamine oxidase expression during development and aging | journal = Neurotoxicology | volume = 25 | issue = 1β2 | pages = 155β65 | date = January 2004 | pmid = 14697890 | doi = 10.1016/S0161-813X(03)00095-0 | bibcode = 2004NeuTx..25..155N }}</ref> Increased MAO-B activity was also found in the [[pineal gland]] of aging rats.<ref name=":1" /> This may contribute to lowered levels of monoamines in aged brain and pineal gland.<ref name=":1" /><ref>{{cite journal | vauthors = Razygraev AV, Arutiunian AV | title = [Pineal gland and brain structures monoamine oxidase activity in rats of different age] | language = Russian | journal = Advances in Gerontology = Uspekhi Gerontologii | volume = 21 | issue = 3 | pages = 402β5 | date = 2008 | pmid = 19432173 }}</ref>
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