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===During pregnancy=== MDMA is a moderately [[teratogenic drug]] (i.e., it is toxic to the fetus).<ref name=vorhees>{{cite journal | vauthors = Vorhees CV | title = Methods for detecting long-term CNS dysfunction after prenatal exposure to neurotoxins | journal = Drug and Chemical Toxicology | volume = 20 | issue = 4 | pages = 387β99 | date = November 1997 | pmid = 9433666 | doi = 10.3109/01480549709003895 }}</ref><ref name=meamar>{{cite journal | vauthors = Meamar R, Karamali F, Sadeghi HM, Etebari M, Nasr-Esfahani MH, Baharvand H | title = Toxicity of ecstasy (MDMA) towards embryonic stem cell-derived cardiac and neural cells | journal = Toxicology in Vitro | volume = 24 | issue = 4 | pages = 1133β8 | date = June 2010 | pmid = 20230888 | doi = 10.1016/j.tiv.2010.03.005 | bibcode = 2010ToxVi..24.1133M | quote = In summary, MDMA is a moderate teratogen that could influence cardiac and neuronal differentiation in the ESC model and these results are in concordance with previous in vivo and in vitro models. }}</ref> [[Uterus|In utero]] exposure to MDMA is associated with a [[neurotoxicity|neuro]]- and [[cardiotoxicity]]<ref name=meamar/> and impaired motor functioning. Motor delays may be temporary during infancy or long-term. The severity of these developmental delays increases with heavier MDMA use.<ref name=Pharm2014 /><ref name=singer>{{cite journal | vauthors = Singer LT, Moore DG, Fulton S, Goodwin J, Turner JJ, Min MO, Parrott AC | title = Neurobehavioral outcomes of infants exposed to MDMA (Ecstasy) and other recreational drugs during pregnancy | journal = Neurotoxicology and Teratology | volume = 34 | issue = 3 | pages = 303β10 | year = 2012 | pmid = 22387807 | pmc = 3367027 | doi = 10.1016/j.ntt.2012.02.001 | bibcode = 2012NTxT...34..303S }}</ref> MDMA has been shown to promote the survival of fetal dopaminergic neurons in culture.<ref>{{cite journal | vauthors = Lipton JW, Tolod EG, Thompson VB, Pei L, Paumier KL, Terpstra BT, Lynch KA, Collier TJ, Sortwell CE | title = 3,4-Methylenedioxy-N-methamphetamine (ecstasy) promotes the survival of fetal dopamine neurons in culture | journal = Neuropharmacology | volume = 55 | issue = 5 | pages = 851β859 | date = October 2008 | pmid = 18655796 | doi = 10.1016/j.neuropharm.2008.06.062 | pmc = 2572681 }}</ref>
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