Editing Homeobox (section)

=== Pax genes ===
{{Main|Pax genes}}
Most Pax genes contain a homeobox and a paired domain that also binds DNA to increase binding specificity, though some Pax genes have lost all or part of the homeobox sequence.<ref>{{cite journal | vauthors = Gruss P, Walther C | title = Pax in development | language = en | journal = Cell | volume = 69 | issue = 5 | pages = 719–22 | date = May 1992 | pmid = 1591773 | doi = 10.1016/0092-8674(92)90281-G | s2cid = 44613005 | url = https://www.cell.com/cell/abstract/0092-8674(92)90281-G | access-date = 2019-12-11 | archive-date = 2021-05-02 | archive-url = https://web.archive.org/web/20210502182428/https://www.cell.com/cell/fulltext/0092-8674(92)90281-G | url-status = live }}</ref> Pax genes function in embryo [[Segmentation (biology)|segmentation]], [[nervous system]] development, generation of the [[frontal eye fields]], [[Skeleton|skeletal]] development, and formation of face structures. [[PAX6|Pax 6]] is a master regulator of eye development, such that the gene is necessary for development of the optic vesicle and subsequent eye structures.<ref>{{cite journal | vauthors = Walther C, Gruss P | title = Pax-6, a murine paired box gene, is expressed in the developing CNS | journal = Development | volume = 113 | issue = 4 | pages = 1435–49 | date = December 1991 | doi = 10.1242/dev.113.4.1435 | pmid = 1687460 }}</ref>