Editing Heme (section)

==Genes==
The following genes are part of the chemical pathway for making heme:
* ''[[ALAD]]'': aminolevulinic acid, δ-, [[dehydratase]] (deficiency causes ala-dehydratase deficiency porphyria)<ref>{{cite journal|last1=Plewinska|first1=Magdalena|last2=Thunell|first2=Stig|last3=Holmberg|first3=Lars|last4=Wetmur|first4=James|last5=Desnick|first5=Robert|title=delta-Aminolevulinate dehydratase deficient porphyria: identification of the molecular lesions in a severely affected homozygote|journal=American Journal of Human Genetics|date=1991|volume=49|issue=1|pages=167–174|pmid=2063868|pmc=1683193}}</ref>
* ''[[ALAS1]]'': aminolevulinate, δ-, synthase 1
* ''[[ALAS2]]'': aminolevulinate, δ-, synthase 2 (deficiency causes sideroblastic/hypochromic anemia)
* ''[[Coproporphyrinogen III oxidase|CPOX]]'': coproporphyrinogen [[oxidase]] (deficiency causes hereditary coproporphyria)<ref>{{cite journal|last1=Aurizi|first1=C.|last2=Lupia Palmieri|first2=G.|last3=Barbieri|first3=L.|last4=Macri|first4=A.|last5=Sorge|first5=F.|last6=Usai|first6=G.|last7=Biolcati|first7=G.|title=Four novel mutations of the coproporphyrinogen III oxidase gene|journal=Cellular and Molecular Biology|date=February 2009|volume=55|issue=1|pages=8–15|pmid=19267996}}</ref>
* ''[[Ferrochelatase|FECH]]'': [[ferrochelatase]] (deficiency causes [[erythropoietic protoporphyria]])
* ''[[HMBS (gene)|HMBS]]'': hydroxymethylbilane [[synthase]] (deficiency causes acute intermittent porphyria)<ref>{{cite journal|last1=Bustad|first1=H. J.|last2=Vorland|first2=M.|last3=Ronneseth|first3=E.|last4=Sandberg|first4=S.|last5=Martinez|first5=A.|last6=Toska|first6=K.|title=Conformational stability and activity analysis of two hydroxymethylbilane synthase mutants, K132N and V215E, with different phenotypic association with acute intermittent porphyria|journal=Bioscience Reports|date=August 8, 2013|volume=33|issue=4|doi=10.1042/BSR20130045|pmid=23815679|pmc=3738108|pages=617–626}}</ref>
* ''[[PPOX]]'': protoporphyrinogen [[oxidase]] (deficiency causes variegate porphyria)<ref>{{Cite journal |last1=Martinez di Montemuros |first1=F. |last2=Di Pierro |first2=E. |last3=Patti |first3=E. |last4=Tavazzi |first4=D. |last5=Danielli |first5=M. G. |last6=Biolcati |first6=G. |last7=Rocchi |first7=E. |last8=Cappellini |first8=M. D. |date=December 2002 |title=Molecular characterization of porphyrias in Italy: a diagnostic flow-chart |url=https://pubmed.ncbi.nlm.nih.gov/12699245/ |journal=Cellular and Molecular Biology (Noisy-Le-Grand, France) |volume=48 |issue=8 |pages=867–876 |issn=0145-5680 |pmid=12699245}}</ref>
* ''[[UROD]]'': [[uroporphyrinogen]] [[decarboxylase]] (deficiency causes porphyria cutanea tarda)<ref>{{cite journal|last1=Badenas|first1=C.|last2=To Figueras|first2=J.|last3=Phillips|first3=J. D.|last4=Warby|first4=C. A.|last5=Muñoz|first5=C.|last6=Herrero|first6=C.|title=Identification and characterization of novel uroporphyrinogen decarboxylase gene mutations in a large series of porphyria cutanea tarda patients and relatives|journal=Clinical Genetics|date=April 2009|volume=75|issue=4|pages=346–353|doi=10.1111/j.1399-0004.2009.01153.x|pmid=19419417|pmc=3804340}}</ref>
* ''[[UROS]]'': [[uroporphyrinogen]] III [[synthase]] (deficiency causes congenital erythropoietic porphyria)