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===Early folk medicine=== [[John Gerard]]'s ''Herball'' (1597) states,<ref name="maud-desc" /> {{Blockquote|[T]he juice of Thornapple, boiled with hog's grease, cureth all inflammations whatsoever, all manner of burnings and scaldings, as well of fire, water, boiling lead, gunpowder, as that which comes by lightning and that in very short time, as myself have found in daily practice, to my great credit and profit.|sign=|source=}} [[William Lewis (scientist)|William Lewis]] reported, in the late 18th century, that the juice could be made into "a very powerful remedy in various convulsive and spasmodic disorders, epilepsy and mania," and was also "found to give ease in external inflammations and [[haemorrhoids]]".<ref>[[William Lewis (scientist)|William Lewis]], [https://chestofbooks.com/health/materia-medica-drugs/Experimental-History-Materia-Medica/Stramonium.html "An Experimental History Of The Materia Medica: Stramonium"]</ref> Henry Hyde Salter discusses ''D. stramonium'' as a treatment for [[asthma]] in his 19th-century work ''On Asthma: its Pathology and Treatment''. Smoking of herbs, including ''D. stramonium'', was thought to provide relief for [[asthma]]tics since [[Ancient History|antiquity]] and into the early 20th century.<ref name="von MutiusDrazen2012">{{cite journal|last1=von Mutius|first1=Erika|last2=Drazen|first2=Jeffrey M.|title=A Patient with Asthma Seeks Medical Advice in 1828, 1928, and 2012|journal=New England Journal of Medicine|volume=366|issue=9|year=2012|pages=827β834|issn=0028-4793|doi=10.1056/NEJMra1102783|pmid=22375974|doi-access=free}}</ref><ref name="Jackson2011" /> The use of smoking ''D. stramonium'' to treat asthma would later wane following new understandings of [[asthma]] as an allergic inflammatory reaction, and developments in pharmacology that provided more effective treatments.<ref name="Jackson2011">{{cite journal|last1=Jackson|first1=Mark|title="Divine Stramonium": The Rise and Fall of Smoking for Asthma|journal=Medical History|volume=54|issue=2|year=2011|pages=171β194|issn=0025-7273|doi=10.1017/S0025727300000235|pmid=20357985|pmc=2844275|doi-access=free}}</ref>
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