Editing Cytosol (section)

===Cytoskeletal sieving===
Although the [[cytoskeleton]] is not part of the cytosol, the presence of this network of filaments restricts the diffusion of large particles in the cell. For example, in several studies tracer particles larger than about 25&nbsp;[[nanometre]]s (about the size of a [[ribosome]])<ref>{{cite journal |author=Cate JH |title=Construction of low-resolution x-ray crystallographic electron density maps of the ribosome |journal=Methods |volume=25 |issue=3 |pages=303–8 |date=November 2001 |pmid=11860284 |doi=10.1006/meth.2001.1242|url=https://zenodo.org/record/1229926 }}</ref>  were excluded from parts of the cytosol around the edges of the cell and next to the nucleus.<ref>{{cite journal |vauthors=Provance DW, McDowall A, Marko M, Luby-Phelps K |title=Cytoarchitecture of size-excluding compartments in living cells |journal=J. Cell Sci. |volume=106 |issue=2 |pages=565–77 |date=1 October 1993|doi=10.1242/jcs.106.2.565 |pmid=7980739 |url=http://jcs.biologists.org/cgi/pmidlookup?view=long&pmid=7980739 }}</ref><ref>{{cite journal |vauthors=Luby-Phelps K, Castle PE, Taylor DL, Lanni F |title=Hindered diffusion of inert tracer particles in the cytoplasm of mouse 3T3 cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue=14 |pages=4910–3 |date=July 1987 |pmid=3474634 |pmc=305216 |doi=10.1073/pnas.84.14.4910|bibcode=1987PNAS...84.4910L |doi-access=free }}</ref> These "excluding compartments" may contain a much denser meshwork of [[actin]] fibres than the remainder of the cytosol. These microdomains could influence the distribution of large structures such as [[ribosome]]s and organelles within the cytosol by excluding them from some areas and concentrating them in others.<ref>{{cite journal |author=Luby-Phelps K |title=Effect of cytoarchitecture on the transport and localization of protein synthetic machinery |journal=J. Cell. Biochem. |volume=52 |issue=2 |pages=140–7 |date=June 1993 |pmid=8366131 |doi=10.1002/jcb.240520205|s2cid=12063324 }}</ref>