Editing Chronobiology (section)

===Effect on learning===
The [[hippocampus]] is a structure in the limbic system that receives projections from ipRGCs. It is required for the consolidation of [[short-term memory|short-term memories]] into [[long-term memory|long-term memories]] as well as spatial orientation and navigation. Depression and heightened serum corticosterone levels are linked to impaired hippocampal learning. Hattar and his team analyzed the T7 mice in the [[Morris water navigation task|Morris water maze (MWM)]], a spatial learning task that places a mouse in a small pool of water and tests the mouse's ability to locate and remember the location of a rescue platform located just below the waterline.  Compared to the T24 mice, the T7 mice took longer to find the platform in subsequent trials and did not exhibit a preference for the quadrant containing the platform. In addition, T7 mice exhibited impaired hippocampal [[long-term potentiation]] (LTP) when subjected to [[Theta Burst Stimulation|theta burst stimulation]] (TBS). Recognition memory was also affected, with T7 mice failing to show preference for novel objects in the novel object recognition test.<ref name=Sauer>{{cite journal|last1=Sauer|first1=Jonas-Frederic|title=Impaired fast-spiking interneuron function in a genetic mouse model of depression|journal=eLife|date=3 March 2015|volume=4|doi=10.7554/elife.04979|pmid=25735038|pmc=4374525 |doi-access=free }}</ref>