Editing Antiandrogen (section)

====Skin and hair conditions====
{{See also|Acne vulgaris#Hormonal agents|Seborrhoeic dermatitis#Antiandrogens|Hirsutism#Medications}}

Antiandrogens are used in the treatment of androgen-dependent [[skin condition|skin]] and [[hair disease|hair condition]]s including acne, seborrhea, hidradenitis suppurativa, hirsutism, and pattern hair loss in women.<ref name="pmid16828411" /> All of these conditions are dependent on androgens, and for this reason, antiandrogens are effective in treating them.<ref name="pmid16828411" /> The most commonly used antiandrogens for these indications are [[cyproterone acetate]] and [[spironolactone]].<ref name="BaranMaibach1998">{{cite book| vauthors = Baran R, Maibach HI |title=Textbook of Cosmetic Dermatology|url=https://books.google.com/books?id=yIVfq5Lpl2EC&pg=PA388|date=1 October 1998|publisher=CRC Press|isbn=978-1-85317-478-0|pages=388–}}</ref> [[Flutamide]] has also been studied extensively for such uses, but has fallen out of favor due to its association with [[hepatotoxicity]].<ref name="MaibachGorouhi2011">{{cite book| vauthors = Maibach HI, Gorouhi F |title=Evidence Based Dermatology|url=https://books.google.com/books?id=V2L1MAoGHVkC&pg=PA526|year=2011|publisher=PMPH-USA|isbn=978-1-60795-039-4|pages=526–}}</ref> [[Bicalutamide]], which has a relatively minimal risk of hepatotoxicity, has been evaluated for the treatment of hirsutism and found effective similarly to flutamide and may be used instead of it.<ref name="WilliamsBigby2009">{{cite book|vauthors=Williams H, Bigby M, Diepgen T, Herxheimer A, Naldi L, Rzany B|title=Evidence-Based Dermatology|url=https://books.google.com/books?id=SbsQij5xkfYC&pg=PA529|date=22 January 2009|publisher=John Wiley & Sons|isbn=978-1-4443-0017-8|pages=529–|access-date=27 December 2016|archive-date=10 January 2023|archive-url=https://web.archive.org/web/20230110085152/https://books.google.com/books?id=SbsQij5xkfYC&pg=PA529|url-status=live}}</ref><ref name="pmid24455796">{{cite journal | vauthors = Erem C | title = Update on idiopathic hirsutism: diagnosis and treatment | journal = Acta Clin Belg | volume = 68 | issue = 4 | pages = 268–74 | year = 2013 | pmid = 24455796 | doi = 10.2143/ACB.3267 | s2cid = 39120534 }}</ref> In addition to AR antagonists, [[oral contraceptive]]s containing [[ethinylestradiol]] are effective in treating these conditions, and may be combined with AR antagonists.<ref name="Becker2001">{{cite book| vauthors = Becker KL |title=Principles and Practice of Endocrinology and Metabolism |url= https://books.google.com/books?id=FVfzRvaucq8C&pg=PA1004 |year=2001|publisher=Lippincott Williams & Wilkins|isbn=978-0-7817-1750-2|pages=1004, 1196}}</ref><ref name="CamachoGharib2012">{{cite book| vauthors = Camacho PM, Gharib H, Sizemore GW |title=Evidence-Based Endocrinology |url=https://books.google.com/books?id=TrLaw_CX1i8C&pg=PA199 |year=2012 |publisher=Lippincott Williams & Wilkins |isbn=978-1-4511-1091-3 |pages=199–}}</ref>