Editing Vancomycin (section)

==Dosing considerations==
The recommended intravenous dosage in adults is 500&nbsp;mg every 6 hours or 1000&nbsp;mg every 12 hours, with modification to achieve a therapeutic range as needed. The recommended oral dosage in the treatment of antibiotic-induced pseudomembranous enterocolitis is 125 to 500&nbsp;mg every 6 hours for 7 to 10 days.<ref name="pmid31644188">{{citation | publisher=National Institute of Diabetes and Digestive and Kidney Diseases | publication-place=Bethesda (MD) | year=2012 | pmid=31644188 | url=http://www.ncbi.nlm.nih.gov/books/NBK548881/ | access-date=25 February 2021 | page= | title=Vancomycin | archive-date=14 May 2021 | archive-url=https://web.archive.org/web/20210514164828/https://www.ncbi.nlm.nih.gov/books/NBK548881/ | url-status=live }}[[File:CC-BY icon.svg|50px]] Text was copied from this source, which is available under a [https://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International License] {{Webarchive|url=https://web.archive.org/web/20171016050101/https://creativecommons.org/licenses/by/4.0/ |date=16 October 2017 }}.</ref>

Dose optimization and target attainment of vancomycin in children involves adjusting the dosage to maximize effectiveness while minimizing the risk of adverse effects, specifically acute kidney injury. Dose optimization is achieved by [[therapeutic drug monitoring]] (TDM), which allows measurement of vancomycin levels in the blood. TDM using [[area under the curve]] (AUC)-guided dosing, preferably with Bayesian forecasting, is recommended to ensure that the AUC0-24h/minimal inhibitory concentration (MIC) ratio is maintained above a certain threshold (400-600) associated with optimal efficacy.<ref name="pmid38325652">{{cite journal | vauthors = Cafaro A, Stella M, Mesini A, Castagnola E, Cangemi G, Mattioli F, Baiardi G | title = Dose optimization and target attainment of vancomycin in children | journal = Clinical Biochemistry | volume = 125 | issue =  | pages = 110728 | date = March 2024 | pmid = 38325652 | doi = 10.1016/j.clinbiochem.2024.110728 | s2cid = 267502279 }}</ref>