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==== mGluR1 and mGluR4 ==== Signal from these two receptors are conveyed in a manner independent of TRPM5. Single umami-sensitive fibres in mice are mostly either "sucrose-best" or "glutamate-best". Within each type there are two subtypes: one shows synergistic activation between monopotassium glutamate and inosine monophosphate, the other does not. The TAS1R1/3 + TRPM5 route uses the "sucrose-best" fibers with synergy, while mGluR1 and mGluR4 use both of the "glutamate-best" subtypes.<ref>{{cite journal |last1=Yasumatsu |first1=Keiko |last2=Ogiwara |first2=Yoko |last3=Takai |first3=Shingo |last4=Yoshida |first4=Ryusuke |last5=Iwatsuki |first5=Ken |last6=Torii |first6=Kunio |last7=Margolskee |first7=Robert F. |last8=Ninomiya |first8=Yuzo |title=Umami taste in mice uses multiple receptors and transduction pathways |journal=The Journal of Physiology |date=March 2012 |volume=590 |issue=5 |pages=1155β1170 |doi=10.1113/jphysiol.2011.211920 |pmid=22183726|pmc=3381822 }}</ref>
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