Editing Treponema pallidum (section)

=====TP0751=====

The TP0751 protein is a protein that is unique to ''T. pallidum'', and it is thought to aid in attachment to the host's extra cellular membrane.<ref name=":02">{{Cite journal |last1=Parker |first1=Michelle L. |last2=Houston |first2=Simon |last3=Pětrošová |first3=Helena |last4=Lithgow |first4=Karen V. |last5=Hof |first5=Rebecca |last6=Wetherell |first6=Charmaine |last7=Kao |first7=Wei-Chien |last8=Lin |first8=Yi-Pin |last9=Moriarty |first9=Tara J. |last10=Ebady |first10=Rhodaba |last11=Cameron |first11=Caroline E. |last12=Boulanger |first12=Martin J. |date=September 2016 |title=The Structure of Treponema pallidum Tp0751 (Pallilysin) Reveals a Non-canonical Lipocalin Fold That Mediates Adhesion to Extracellular Matrix Components and Interactions with Host Cells |journal=PLOS Pathogens |volume=12 |issue=9 |pages=e1005919 |doi=10.1371/journal.ppat.1005919 |doi-access=free |issn=1553-7374 |pmc=5040251 |pmid=27683203}}</ref> Since this protein aids in the attachment to the host, it sits on the surface of the cells, and in 2005, it was discovered that the TP0751 protein will attach to the [[laminin]] component in the host's [[extracellular matrix]].<ref name=":12">{{Cite journal |last1=Cameron |first1=Caroline E. |last2=Brouwer |first2=Nathan L. |last3=Tisch |first3=Lisa M. |last4=Kuroiwa |first4=Janelle M. Y. |date=November 2005 |title=Defining the interaction of the Treponema pallidum adhesin Tp0751 with laminin |journal=Infection and Immunity |volume=73 |issue=11 |pages=7485–7494 |doi=10.1128/IAI.73.11.7485-7494.2005 |issn=0019-9567 |pmc=1273862 |pmid=16239550}}</ref> With that, it is thought that the TP0751 protein plays a key role in dissemination with the host.<ref name=":12" /><ref name=":02" />