Editing Thyroid (section)

===Regulation===

The production of thyroxine and triiodothyronine is primarily regulated by thyroid-stimulating hormone (TSH), released by the [[anterior pituitary]] gland. TSH release in turn is stimulated by [[thyrotropin releasing hormone]] (TRH), released in a pulsatile manner from the [[hypothalamus]].{{sfn|Greenspan's|2011|p=174}} The thyroid hormones provide [[negative feedback]] to the [[thyrotrope]]s TSH and TRH: when the thyroid hormones are high, TSH production is suppressed. This negative feedback also occurs when levels of TSH are high, causing TRH production to be suppressed.{{sfn|Greenspan's|2011|p=177}}

TRH is secreted at an increased rate in situations such as cold exposure in order to stimulate [[thermogenesis]].{{sfn|Guyton & Hall|2011|p=896}} In addition to being suppressed by the presence of thyroid hormones, TSH production is blunted by [[dopamine]], [[somatostatin]], and [[glucocorticoid]]s.{{sfn|Harrison's|2011|pp=2215}}