Editing Shotgun sequencing (section)

==Newer sequencing technologies==
The classical shotgun sequencing was based on the Sanger sequencing method: this was the most advanced technique for sequencing genomes from about 1995–2005. The shotgun strategy is still applied today, however using other sequencing technologies, such as [[DNA sequencing#Next-generation methods|short-read sequencing]] and [[long-read sequencing]].

Short-read or "next-gen" sequencing produces shorter reads (anywhere from 25–500bp) but many hundreds of thousands or millions of reads in a relatively short time (on the order of a day).<ref>{{cite journal |last1=Voelkerding |first1=Karl V |last2=Dames |first2=Shale A |last3=Durtschi |first3=Jacob D |title=Next-Generation Sequencing: From Basic Research to Diagnostics |journal=Clinical Chemistry |date=1 April 2009 |volume=55 |issue=4 |pages=641–658 |doi=10.1373/clinchem.2008.112789 |doi-access=free |pmid=19246620}}</ref>
This results in high coverage, but the assembly process is much more computationally intensive. These technologies are vastly superior to Sanger sequencing due to the high volume of data and the relatively short time it takes to sequence a whole genome.<ref>{{cite journal |last1=Metzker |first1=Michael L. |title=Sequencing technologies — the next generation |journal=Nature Reviews Genetics |date=January 2010 |volume=11 |issue=1 |pages=31–46 |doi=10.1038/nrg2626 |pmid=19997069 |citeseerx=10.1.1.719.3885 |s2cid=205484500}}</ref>