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====Hokuriku, Kantō, and Chūbu regions (Uesugi Kenshin)==== [[File:Uesugi Kenshin Portrait from Uesugi Shrine.png|thumb|[[Uesugi Kenshin]]]] In 1546, [[Hōjō Ujiyasu]] defeated [[Uesugi Tomosada (16th century)|Uesugi Tomosada]] at the [[Siege of Kawagoe Castle]], and the [[Later Hōjō clan]] established its power in the [[Kantō region]].<ref name="jk061222"/> [[Uesugi Kenshin]] (Nagao Kagetora) was a ''sengoku daimyo'' based in [[Echigo Province]] who fought various ''sengoku daimyo'' and increased his power through aggressive invasions. After unifying Echigo in 1551, he invaded the Kantō region several times from 1552 to 1569 and fought against Hōjō Ujiyasu. He also invaded the territory of [[Takeda Shingen]], who ruled [[Kai Province|Kai]] and [[Shinano Province]]s from 1553 to 1573, and fought in the [[Battle of Kawanakajima]] five times between 1553 and 1564. In 1559, Kenshin had an audience with [[Emperor Ōgimachi]] and the 13th Shogun, Ashikaga Yoshiteru. When [[Imagawa Yoshimoto]] was killed by [[Oda Nobunaga]]'s forces at the [[Battle of Okehazama]] in 1560, the [[:ja:甲相駿三国同盟|Alliance Kai-Sagami-Suruga]] formed in 1554 between Takeda Shingen in Kai, Hojo Ujiyasu in [[Sagami Province|Sagami]], and Imagawa Yoshimoto in [[Suruga Province|Suruga]] was broken. Kenshin used this as an opportunity to seize Hojo Ujiyasu's territories one by one, and cornered the Later Hōjō clan at the [[Siege of Odawara (1561)|Siege of Odawara]] in 1561, but was unable to defeat them. On his return from the Siege of Odawara, he performed a ceremony at the [[Tsurugaoka Hachimangū]] and assumed the position of ''[[Kanrei|kantō kanrei]]''. Kenshin made peace with Hōjō Ujiyasu, who ceded part of his territory to him in 1569, and made Takeda Shingen a common enemy of Kenshin and Ujiyasu, but Shingen died of illness in 1573. After Takeda Shingen's death, he fell out with Oda Nobunaga and destroyed the Noto Hatakeyama clan, which was close to Nobunaga, at the [[Siege of Nanao]] in 1577, pacifying [[Noto Province]]. He then defeated Oda Nobunaga's forces at the [[Battle of Tedorigawa]]. However, he died of a cerebral hemorrhage in 1578 at the young age of 49.<ref name="kotoken">{{cite web|url=https://kotobank.jp/word/%E4%B8%8A%E6%9D%89%E8%AC%99%E4%BF%A1-33780|archive-url=https://web.archive.org/web/20231225094255/https://kotobank.jp/word/%E4%B8%8A%E6%9D%89%E8%AC%99%E4%BF%A1-33780|script-title=ja:上杉謙信|language=ja|publisher=Kotobank|date=|archive-date=25 December 2023|access-date=17 April 2024}}</ref><ref name="toukenken">{{cite web|url=https://www.touken-world.jp/tips/33844/|archive-url=https://web.archive.org/web/20240417042219/https://www.touken-world.jp/tips/33844/|script-title=ja:上杉謙信の歴史|language=ja|publisher=The Nagoya Japanese Sword Museum Nagoya Touken World|date=|archive-date=17 April 2024|access-date=17 April 2024}}</ref>
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