Editing RNA (section)

==== Long non-coding RNAs ====
{{See also|Long non-coding RNA|l1=Long Non-coding RNA}}

Next to be linked to regulation were [[XIST|Xist]] and other [[long noncoding RNA]]s associated with [[X chromosome inactivation]].&nbsp; Their roles, at first mysterious, were shown by [[Jeannie T. Lee]] and others to be the [[RNA silencing|silencing]] of blocks of chromatin via recruitment of [[Polycomb-group proteins|Polycomb]] complex so that messenger RNA could not be transcribed from them.<ref>{{cite journal | vauthors = Zhao J, Sun BK, Erwin JA, Song JJ, Lee JT | year = 2008 | title = Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome | journal = Science | volume = 322 | issue = 5902| pages = 750–56 | pmid = 18974356 | doi = 10.1126/science.1163045 | pmc = 2748911 | bibcode = 2008Sci...322..750Z }}</ref> Additional lncRNAs, currently defined as RNAs of more than 200 base pairs that do not appear to have coding potential,<ref name="Rinn-2012">{{cite journal | vauthors = Rinn JL, Chang HY | year = 2012 | title = Genome regulation by long noncoding RNAs | journal = Annu. Rev. Biochem. | volume = 81 | pages = 1–25 | doi = 10.1146/annurev-biochem-051410-092902 | pmid = 22663078 | pmc = 3858397 }}</ref> have been found associated with regulation of [[stem cell]] [[pluripotency]] and [[cell division]].<ref name="Rinn-2012" />