Editing Prion (section)

==== PrP and stem cell renewal ====
A 2006 article from the Whitehead Institute for Biomedical Research indicates that PrP expression on stem cells is necessary for an organism's self-renewal of [[bone marrow]]. The study showed that all long-term [[hematopoietic stem cell]]s express PrP on their cell membrane and that hematopoietic tissues with PrP-null stem cells exhibit increased sensitivity to cell depletion.<ref>{{cite journal | vauthors = Zhang CC, Steele AD, Lindquist S, Lodish HF | title = Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 7 | pages = 2184–9 | date = February 2006 | pmid = 16467153 | pmc = 1413720 | doi = 10.1073/pnas.0510577103 | doi-access = free | bibcode = 2006PNAS..103.2184Z }}</ref>