Editing Positron emission tomography (section)

=== Bio-distribution studies ===
In pre-clinical trials, a new drug can be radiolabeled and injected into animals. Such scans are referred to as biodistribution studies. The information regarding drug uptake, retention and elimination over time can be obtained quickly and cost-effectively compare to the older technique of killing and dissecting the animals. Commonly, drug occupancy at a purported site of action can be inferred indirectly by competition studies between unlabeled drug and radiolabeled compounds to bind with specificity to the site. A single radioligand can be used this way to test many potential drug candidates for the same target. A related technique involves scanning with radioligands that compete with an [[Endogeny (biology)|endogenous]] (naturally occurring) substance at a given receptor to demonstrate that a drug causes the release of the natural substance.<ref>{{cite journal | vauthors = Laruelle M | title = Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review | journal = Journal of Cerebral Blood Flow and Metabolism | volume = 20 | issue = 3 | pages = 423–51 | date = March 2000 | pmid = 10724107 | doi = 10.1097/00004647-200003000-00001 | doi-access = free }}</ref>