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===Microbiome=== {{main|Placental microbiome}} The placenta is traditionally thought to be [[Asepsis|sterile]], but recent research suggests that a resident, [[Nonpathogenic organisms|non-pathogenic]], and diverse population of [[microorganisms]] may be present in healthy tissue. However, whether these microbes exist or are clinically important is highly controversial and is the subject of active research.<ref name="Per2017">{{cite journal | vauthors = Perez-MuΓ±oz ME, Arrieta MC, Ramer-Tait AE, Walter J | title = A critical assessment of the "sterile womb" and "in utero colonization" hypotheses: implications for research on the pioneer infant microbiome | journal = Microbiome | volume = 5 | issue = 1 | pages = 48 | date = April 2017 | pmid = 28454555 | pmc = 5410102 | doi = 10.1186/s40168-017-0268-4 | doi-access = free }}</ref><ref name="MorKwon2015">{{cite journal | vauthors = Mor G, Kwon JY | title = Trophoblast-microbiome interaction: a new paradigm on immune regulation | journal = American Journal of Obstetrics and Gynecology | volume = 213 | issue = 4 Suppl | pages = S131βS137 | date = October 2015 | pmid = 26428492 | pmc = 6800181 | doi = 10.1016/j.ajog.2015.06.039 }}</ref><ref name="PrinceAntony2014">{{cite journal | vauthors = Prince AL, Antony KM, Chu DM, Aagaard KM | title = The microbiome, parturition, and timing of birth: more questions than answers | journal = Journal of Reproductive Immunology | volume = 104-105 | pages = 12β19 | date = October 2014 | pmid = 24793619 | pmc = 4157949 | doi = 10.1016/j.jri.2014.03.006 }}</ref><ref>{{cite journal | vauthors = Hornef M, Penders J | title = Does a prenatal bacterial microbiota exist? | language = En | journal = Mucosal Immunology | volume = 10 | issue = 3 | pages = 598β601 | date = May 2017 | pmid = 28120852 | doi = 10.1038/mi.2016.141 | doi-access = free }}</ref>
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