Editing Phosphodiesterase inhibitor (section)

===PDE10 selective inhibitors===
[[Papaverine]], an [[opium]] [[alkaloid]], has been reported to act as a PDE10 inhibitor.<ref>{{cite journal | pmc = 2748940 | pmid=19066855 | doi=10.1007/s00213-008-1419-x | volume=203 | issue=4 | title=Evaluating the antipsychotic profile of the preferential PDE10A inhibitor, papaverine | date=May 2009 | journal=Psychopharmacology | pages=723–35 |vauthors=Weber M, Breier M, Ko D, Thangaraj N, Marzan DE, Swerdlow NR }}</ref><ref>Inhibitory Mechanism of Papaverine on Carbachol-Induced Contraction in Bovine Trachea; Takeharu Kaneda1,*, Yukako Takeuchi1, Hirozumi Matsui1, Kazumasa Shimizu1, Norimoto Urakawa1,and Shinjiro Nakajyo, Division of Veterinary Pharmacology, Nippon Veterinary and Animal Science University; http://www.jstage.jst.go.jp/article/jphs/98/3/275/_pdf{{Dead link|date=May 2020 |bot=InternetArchiveBot |fix-attempted=yes }}</ref><ref>{{cite journal | doi=10.1016/0024-3205(71)90086-5 | pmid=4325052 | volume=10 | issue=3 | title=Papaverine - induced inhibition of phosphodiesterase activity in various mammalian tissues | journal=Life Sciences | pages=133–144| year=1971 | last1=Pöch | first1=G. | last2=Kukovetz | first2=W.R. }}</ref> 
PDE10A is almost exclusively expressed in the [[striatum]] and subsequent increase in cAMP and cGMP after PDE10A inhibition (e.g. by [[papaverine]]) is "a novel therapeutic avenue in the discovery of antipsychotics".<ref>Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats; An Torremans, Abdellah Ahnaou, An Van Hemelrijck, Roel Straetemans, Helena Geys, Greet Vanhoof, Theo F. Meert, and Wilhelmus H. Drinkenburg; {{cite web |url=http://www.ane.pl/pdf/7002.pdf |title=Archived copy |access-date=2011-08-27 |url-status=live |archive-url=https://web.archive.org/web/20111007095852/http://www.ane.pl/pdf/7002.pdf |archive-date=2011-10-07 }}</ref>

<!-- possible items to mention: more other uses as a pharmacological agent, contraindications, unsuccessfully trialed  oral ? amrinone? for long-term CCF Rx..... any more ???

Please go ahead and add..... -->