Editing Peripheral membrane protein (section)

===Membrane-targeting domains (“lipid clamps")===
[[Image:1ptr.png|thumb|right|170px| [[C1 domain]] of PKC-delta (1ptr)
Middle plane of the lipid bilayer – black dots. Boundary of the hydrocarbon core region – blue dots (cytoplasmic side). Layer of lipid phosphates – yellow dots.]]
Membrane-targeting domains associate specifically with head groups of their lipid ligands embedded into the membrane. These lipid ligands are present in different concentrations in distinct types of biological membranes (for example, [[Phosphatidylinositol 3-phosphate|PtdIns3P]] can be found mostly in membranes of early [[endosome]]s, [[Phosphatidylinositol (3,5)-bisphosphate|PtdIns(3,5)P2]] in late [[endosome]]s, and [[Phosphatidylinositol 4-phosphate|PtdIns4P]] in the [[Golgi apparatus|Golgi]]).<ref name="Cho"/> Hence, each domain is targeted to a specific membrane.
*[[C1 domain]]s and [[Phorbol|phorbol esters]].
*[[C2 domain]]s bind [[phosphatidylserine]], [[phosphatidylcholine]] or [[Phosphatidylinositol (3,4)-bisphosphate|PtdIns(3,4)P2]] or [[Phosphatidylinositol (4,5)-bisphosphate|PtdIns(4,5)P2]].
*[[Pleckstrin homology domain]]s, [[PX domain]]s, and [[Tubby protein|Tubby domains]]  bind different [[Phosphatidylinositol|phosphoinositides]]
*[[FYVE domain]]s are more specific for PtdIns3P.
*[[ENTH domain]]s bind [[Phosphatidylinositol (3,4)-bisphosphate|PtdIns(3,4)P2]] or [[Phosphatidylinositol (4,5)-bisphosphate|PtdIns(4,5)P2]].
*[[ANTH]] domain binds PtdIns(4,5)P2.
*Proteins from [[Merlin (protein)|ERM (ezrin/radixin/moesin) family]] bind PtdIns(4,5)P2.
*Other [[Phosphatidylinositol|phosphoinositide]]-binding proteins include [[phosphotyrosine]]-binding domain and certain [[PDZ domain]]s. They bind PtdIns(4,5)P2.
*Discoidin domains of blood [[coagulation]] factors
*[[ENTH]], VHS and [[ANTH]] domains