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====Choline==== {{Main|Choline}} Choline is an essential nutrient.<ref>{{cite web |title=Dietary Intakes of Choline |url=https://www.ars.usda.gov/ARSUserFiles/80400530/pdf/dbrief/9_choline_intakes_0708.pdf |website=usda.gov |publisher=United States Department of Agriculture |access-date=May 8, 2021}}</ref><ref>{{cite web |title=Choline |url=https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/#:~:text=Choline%20is%20an%20essential%20nutrient,phospholipids%20vital%20for%20cell%20membranes. |website=nih.gov |publisher=National Institutes of Health |access-date=May 8, 2021}}</ref><ref>{{cite journal |last1=Zeisel |first1=Steven H |last2=da Costa |first2=Kerry-Ann |title=Choline: an essential nutrient for public health |journal=Nutrition Reviews |date=November 1, 2009 |volume=67 |issue=11 |pages=615β623 |doi=10.1111/j.1753-4887.2009.00246.x |pmid=19906248 |url= |pmc=2782876 }}</ref> The cholines are a family of water-soluble [[quaternary ammonium compound]]s.<ref name="Choline HMDB">{{cite encyclopedia|title=Choline|url=http://www.hmdb.ca/metabolites/hmdb00097|website=Human Metabolome Database|publisher=The Metabolomics Innovation Centre, University of Alberta, Edmonton, Canada|access-date=13 September 2016|date=17 August 2016}}</ref><ref>Britannica, The Editors of Encyclopaedia. "choline". Encyclopedia Britannica, 11 Dec. 2013, https://www.britannica.com/science/choline. Accessed 17 February 2022.</ref> Choline is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.<ref>National Center for Biotechnology Information (2022). PubChem Compound Summary for CID 305, Choline. Retrieved February 17, 2022 from https://pubchem.ncbi.nlm.nih.gov/compound/Choline.</ref> Healthy humans fed artificially composed diets that are deficient in choline develop fatty liver, liver damage, and muscle damage. Choline was not initially classified as essential because the human body can produce choline in small amounts through phosphatidylcholine metabolism.<ref>{{cite web |title=Choline |url=https://lpi.oregonstate.edu/mic/other-nutrients/choline |website=Micronutrient Information Center |date=28 April 2014 |publisher=Oregon State University |access-date=May 8, 2021}}</ref>
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