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==Epidemiology== About 1 in 4,000 children in the United States will develop mitochondrial disease by the age of 10 years. Up to 4,000 children per year in the US are born with a type of mitochondrial disease.<ref>[http://biochemgen.ucsd.edu/mmdc/brochure.htm The Mitochondrial and Metabolic Disease Center<!-- Bot generated title -->]</ref> Because mitochondrial disorders contain many variations and subsets, some particular mitochondrial disorders are very rare. The average number of births per year among women at risk for transmitting mtDNA disease is estimated to approximately 150 in the [[United Kingdom]] and 800 in the [[United States]].<ref name="GormanGrady2015">{{cite journal |last1=Gorman |first1=Gráinne S. |last2=Grady |first2=John P. |last3=Ng |first3=Yi |last4=Schaefer |first4=Andrew M. |last5=McNally |first5=Richard J. |last6=Chinnery |first6=Patrick F. |last7=Yu-Wai-Man |first7=Patrick |last8=Herbert |first8=Mary |last9=Taylor |first9=Robert W. |last10=McFarland |first10=Robert |last11=Turnbull |first11=Doug M. |title=Mitochondrial Donation — How Many Women Could Benefit? |journal=New England Journal of Medicine |date=26 February 2015 |volume=372 |issue=9 |pages=885–887 |doi=10.1056/NEJMc1500960 |pmid=25629662 |pmc=4481295 }}</ref>
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