Editing Metabolic pathway (section)

===Targeting Heme===

[[Heme]], an important prosthetic group present in Complexes I, II, and IV can also be targeted, since heme biosynthesis and uptake have been correlated with increased cancer progression.<ref>{{cite journal | vauthors = Hooda J, Cadinu D, Alam MM, Shah A, Cao TM, Sullivan LA, Brekken R, Zhang L | display-authors = 6 | title = Enhanced heme function and mitochondrial respiration promote the progression of lung cancer cells | journal = PLOS ONE | volume = 8 | issue = 5 | pages = e63402 | date = 2013 | pmid = 23704904 | pmc = 3660535 | doi = 10.1371/journal.pone.0063402 | doi-access = free | bibcode = 2013PLoSO...863402H }}</ref> Various molecules can inhibit heme via different mechanisms. For instance, [[succinylacetone]] has been shown to decrease heme concentrations by inhibiting δ-aminolevulinic acid in murine erythroleukemia cells.<ref>{{cite journal | vauthors = Ebert PS, Hess RA, Frykholm BC, Tschudy DP | title = Succinylacetone, a potent inhibitor of heme biosynthesis: effect on cell growth, heme content and delta-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells | journal = Biochemical and Biophysical Research Communications | volume = 88 | issue = 4 | pages = 1382–1390 | date = June 1979 | pmid = 289386 | doi = 10.1016/0006-291x(79)91133-1 }}</ref> The primary structure of heme-sequestering peptides, such as HSP1 and HSP2, can be modified to downregulate heme concentrations and reduce proliferation of non-small lung cancer cells.<ref>{{cite journal | vauthors = Sohoni S, Ghosh P, Wang T, Kalainayakan SP, Vidal C, Dey S, Konduri PC, Zhang L | display-authors = 6 | title = Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non-Small Cell Lung Cancer Cells | journal = Cancer Research | volume = 79 | issue = 10 | pages = 2511–2525 | date = May 2019 | pmid = 30902795 | doi = 10.1158/0008-5472.CAN-18-2156 | s2cid = 85456667 }}</ref>