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=== Strategies for engineered negligible senescence === {{Main|Strategies for engineered negligible senescence|Genetics of aging}} Another proposed life extension technology aims to combine existing and predicted future biochemical and genetic techniques. SENS proposes that rejuvenation may be obtained by removing aging damage via the use of [[stem cell]]s and [[tissue engineering]], [[telomere]]-lengthening machinery, [[allotopic expression]] of [[mitochondrial]] proteins, targeted ablation of cells, [[immunotherapy|immunotherapeutic]] clearance, and novel [[lysosome|lysosomal]] [[hydrolases]].<ref>{{Cite book | vauthors = de Grey A, Rae M |author-link=Aubrey de Grey | title=Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime |publisher=[[St. Martin's Press]] |year=2007 |location=[[New York City]] |isbn= 978-0-312-36706-0 |oclc=132583222|title-link=Ending Aging }}{{Page needed|date=September 2010}}</ref> While some [[Biogerontology|biogerontologists]] find these ideas "worthy of discussion",<ref>{{cite web | vauthors = Pontin J | date = 11 July 2006 | url = http://www.technologyreview.com/sens/ | title = Is Defeating Aging Only A Dream? | work = Technology Review | access-date = 15 February 2013 | archive-date = 11 September 2012 | archive-url = https://archive.today/20120911155923/http://www.technologyreview.com/sens/ | url-status = dead }}</ref><ref>{{cite news | vauthors = Garreau J | date = 31 October 2007 | url = https://www.washingtonpost.com/wp-dyn/content/article/2007/10/30/AR2007103002222.html?hpid=features1&hpv=national | title = The Invincible Man | newspaper = Washington Post }}</ref> others contend that the alleged benefits are too speculative given the current state of technology, referring to it as "fantasy rather than science".<ref name=Holliday /><ref name="EMBOSENS" />
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