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==Epidemiology== Prevalence of disease in a rigorous [[meta-analysis]] in 2017 was 46 patients per million.<ref name="Greenberg2019Review" /> The earliest published prevalence was in 2000 and put at 5 per million.<ref name="Greenberg2019Review" /> A 2017 study in Ireland reported 112 per million.<ref name="Greenberg2019Review" /> It is not believed that the disease prevalence is increasing with time, but rather diagnostics and reporting are improving.<ref name="Greenberg2019Review" /> Estimates of the mean age of onset range from 61 to 68 years old.<ref name="Greenberg2019Review" />
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