Editing Hypothyroidism (section)

===Subclinical===
Subclinical hypothyroidism is a biochemical diagnosis characterized by an elevated serum TSH level, but with a normal serum free thyroxine level.<ref name="Peters 2017">{{cite journal |last1=Peeters |first1=Robin P. |title=Subclinical Hypothyroidism |journal=New England Journal of Medicine |date=29 June 2017 |volume=376 |issue=26 |pages=2556–2565 |doi=10.1056/NEJMcp1611144|pmid=28657873 |s2cid=56184355 }}</ref><ref name=Bona2013>{{cite journal | vauthors = Bona G, Prodam F, Monzani A | title = Subclinical hypothyroidism in children: natural history and when to treat | journal = Journal of Clinical Research in Pediatric Endocrinology | volume = 5 Suppl 1 | issue = 4 | pages = 23–8 | year = 2013 | pmid = 23154159 | pmc = 3608012 | doi = 10.4274/jcrpe.851 | type = Review }}</ref><ref name=Fatourechi/> The incidence of subclinical hypothyroidism is estimated to be 3-15% and a higher incidence is seen in elderly people, females and those with lower iodine levels.<ref name="Peters 2017" /> Subclinical hypothyroidism is most commonly caused by autoimmune thyroid diseases, especially [[Hashimoto's thyroiditis]].<ref name=Baumgartner2014>{{cite journal | vauthors = Baumgartner C, Blum MR, Rodondi N | title = Subclinical hypothyroidism: summary of evidence in 2014 | journal = [[Swiss Medical Weekly]] | volume = 144 | pages = w14058 | date = December 2014 | pmid = 25536449 | doi = 10.4414/smw.2014.14058 | type = Review | doi-access = free }}</ref>  The presentation of subclinical hypothyroidism is variable and classic signs and symptoms of hypothyroidism may not be observed.<ref name=Bona2013/> Of people with subclinical hypothyroidism, a proportion will develop overt hypothyroidism each year. In those with detectable antibodies against thyroid peroxidase (TPO), this occurs in 4.3%, while in those with no detectable antibodies, this occurs in 2.6%.<ref name=Garber/> In addition to detectable anti-TPO antibodies, other risk factors for conversion from subclinical hypothyroidism to overt hypothyroidism include female sex or in those with higher TSH levels or lower level of normal free T<sub>4</sub> levels.<ref name="Peters 2017" /> Those with subclinical hypothyroidism and detectable anti-TPO antibodies who do not require treatment should have repeat thyroid function tested more frequently (e.g. every 6 months) compared with those who do not have antibodies.<ref name=So2012/><ref name="Peters 2017" />