Editing Histone (section)

==== Glutamine serotonylation ====
Recently it has been shown, that the addition of a [[serotonin]] group to the position 5 glutamine of H3, happens in serotonergic cells such as neurons. This is part of the differentiation of the serotonergic cells. This post-translational modification happens in conjunction with the H3K4me3 modification. The serotonylation potentiates the binding of the general transcription factor [[Transcription factor II D|TFIID]] to the [[TATA box]].<ref>{{cite journal | vauthors = Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I | title = Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3 | journal = Nature | volume = 567 | issue = 7749 | pages = 535–539 | date = March 2019 | pmid = 30867594 | pmc = 6557285 | doi = 10.1038/s41586-019-1024-7 | bibcode = 2019Natur.567..535F }}</ref>