Editing Hippocampus (section)

====Between systems model====
The '''between-systems memory interference model''' describes the inhibition of non-hippocampal systems of memory during concurrent hippocampal activity.<ref name="Packard_2013">{{cite journal | vauthors = Packard MG, Goodman J | title = Factors that influence the relative use of multiple memory systems | journal = Hippocampus | volume = 23 | issue = 11 | pages = 1044–1052 | date = November 2013 | pmid = 23929809 | doi = 10.1002/hipo.22178 }}</ref>  Specifically it was found that when the hippocampus was inactive, non-hippocampal systems located elsewhere in the brain were found to [[Memory consolidation|consolidate]] memory in its place. However, when the hippocampus was reactivated, [[Engram (neuropsychology)|memory traces]] consolidated by non-hippocampal systems were not recalled, suggesting that the hippocampus interferes with [[long-term memory]] consolidation in other memory-related systems.<ref>{{cite journal | vauthors = Sparks FT, Lehmann H, Sutherland RJ | title = Between-systems memory interference during retrieval | journal = The European Journal of Neuroscience | volume = 34 | issue = 5 | pages = 780–786 | date = September 2011 | pmid = 21896061 | doi = 10.1111/j.1460-9568.2011.07796.x | s2cid = 25745773 }}</ref>

One of the major implications that this model illustrates is the dominant effects of the hippocampus on non-hippocampal networks when information is incongruent. With this information in mind, future directions could lead towards the study of these non-hippocampal memory systems through hippocampal inactivation, further expanding the labile constructs of memory. Additionally, many theories of memory are holistically based around the hippocampus. This model could add beneficial information to hippocampal research and memory theories such as the [[multiple trace theory]].<ref name="Moscovitch_2005">{{cite journal | vauthors = Moscovitch M, Rosenbaum RS, Gilboa A, Addis DR, Westmacott R, Grady C, McAndrews MP, Levine B, Black S, Winocur G, Nadel L | title = Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory | journal = Journal of Anatomy | volume = 207 | issue = 1 | pages = 35–66 | date = July 2005 | pmid = 16011544 | pmc = 1571502 | doi = 10.1111/j.1469-7580.2005.00421.x | department = Review }}</ref><ref name = "Moscovitch_2024">{{cite book | vauthors = Moscovitch M, Gilboa A | chapter = Systems consolidation, transformation and reorganization: Multiple trace theory, trace transformation theory and their competitors. | veditors = Kahana MJ, Wagner AD | title = The Oxford Handbook of Human Memory, Two Volume Pack: Foundations and Applications | publisher = Oxford University Press | date = June 2024 | isbn = 978-0-19-091798-2 | doi = 10.1093/oxfordhb/9780190917982.013.43 | department = Review }}</ref> Lastly, the between-system memory interference model allows researchers to evaluate their results on a [[Systems neuroscience|multiple-systems model]], suggesting that some effects may not be simply mediated by one portion of the brain.<ref name="Ferbinteanu_2019">{{cite journal | vauthors = Ferbinteanu J | title = Memory systems 2018 - Towards a new paradigm | journal = Neurobiology of Learning and Memory | volume = 157 | issue = | pages = 61–78 | date = January 2019 | pmid = 30439565 | pmc = 6389412 | doi = 10.1016/j.nlm.2018.11.005 | department = Review }}</ref>