Editing Heme (section)

===Cancer===
There is an association between high intake of heme iron sourced from meat and increased risk of [[colorectal cancer]] via [[nitrosamine formation during digestion]] (N-nitroso).<ref>{{Cite journal |last1=Bastide |first1=Nadia M. |last2=Pierre |first2=Fabrice H. F. |last3=Corpet |first3=Denis E. |date=Feb 2011 |title=Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved |url=https://pubmed.ncbi.nlm.nih.gov/21209396/ |journal=Cancer Prevention Research (Philadelphia, Pa.) |volume=4 |issue=2 |pages=177–184 |doi=10.1158/1940-6207.CAPR-10-0113 |issn=1940-6215 |pmid=21209396}}</ref>

The [[American Institute for Cancer Research]] (AICR) and World Cancer Research Fund International (WCRF) concluded in a 2018 report that there is limited but suggestive evidence that foods containing heme iron increase risk of colorectal cancer.<ref>[https://www.wcrf.org/wp-content/uploads/2021/02/Colorectal-cancer-report.pdf "Diet, nutrition, physical activity and colorectal cancer"]. wcrf.org. Retrieved 12 February 2022.</ref> A 2019 review found that heme iron intake is associated with increased [[breast cancer]] risk.<ref>{{cite journal|author=Chang, Vicky C; Cotterchio, Michelle; Khoo, Edwin|year=2019|title=Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis|journal=[[BMC Cancer]]|volume=19|issue=1|pages=543|doi=10.1186/s12885-019-5642-0|pmid=31170936|pmc=6555759|doi-access=free}}</ref>