Editing Golgi apparatus (section)

===Model 4: Rapid partitioning in a mixed Golgi===
* This rapid partitioning model is the most drastic alteration of the traditional vesicular trafficking point of view. Proponents of this model hypothesize that the Golgi works as a single unit, containing domains that function separately in the processing and export of protein cargo. Cargo from the ER move between these two domains, and randomly exit from any level of the Golgi to their final location. This model is supported by the observation that cargo exits the Golgi in a pattern best described by exponential kinetics. The existence of domains is supported by fluorescence microscopy data.<ref name="Glick-2011"/>
** '''Strengths:''' Notably, this model explains the exponential kinetics of cargo exit of both large and small proteins, whereas other models cannot.<ref name="Glick-2011"/>
** '''Weaknesses:''' This model cannot explain the transport kinetics of large protein cargo, such as collagen. This model falls short on explaining the observation of discrete compartments and polarized biochemistry of the Golgi cisternae. It also does not explain formation and disintegration of the Golgi network, nor the role of COPI vesicles.<ref name="Glick-2011"/>