Editing Feedback (section)

===Biology===
{{Main|Biological interaction}}{{See also|Homeostasis|Allostasis}}
In [[biology|biological]] systems such as [[organism]]s, [[ecosystem]]s, or the [[biosphere]], most parameters must stay under control within a narrow range around a certain optimal level under certain environmental conditions. The deviation of the optimal value of the controlled parameter can result from the changes in internal and external environments. A change of some of the environmental conditions may also require change of that range to change for the system to function. The value of the parameter to maintain is recorded by a reception system and conveyed to a regulation module via an information channel. An example of this is [[insulin oscillation]]s.

Biological systems contain many types of regulatory circuits, both positive and negative. As in other contexts, ''positive'' and ''negative'' do not imply that the feedback causes ''good'' or ''bad'' effects. A negative feedback loop is one that tends to slow down a process, whereas the positive feedback loop tends to accelerate it. The [[mirror neuron]]s are part of a social feedback system, when an observed action is "mirrored" by the brain—like a self-performed action.

Normal tissue integrity is preserved by feedback interactions between diverse cell types mediated by adhesion molecules and secreted molecules that act as mediators; failure of key feedback mechanisms in cancer disrupts tissue function.<ref>{{cite journal|last1=Vlahopoulos|first1=SA|last2=Cen|first2=O|last3=Hengen|first3=N|last4=Agan|first4=J|last5=Moschovi|first5=M|last6=Critselis|first6=E|last7=Adamaki|first7=M|last8=Bacopoulou|first8=F|last9=Copland|first9=JA|last10=Boldogh|first10=I|last11=Karin|first11=M|last12=Chrousos|first12=GP|title=Dynamic aberrant NF-κB spurs tumorigenesis: A new model encompassing the microenvironment.|journal=Cytokine & Growth Factor Reviews|date=20 June 2015|pmid=26119834|doi=10.1016/j.cytogfr.2015.06.001|volume=26|issue=4|pages=389–403|pmc=4526340}}</ref>
In an injured or infected tissue, inflammatory mediators elicit feedback responses in cells, which alter gene expression, and change the groups of molecules expressed and secreted, including molecules that induce diverse cells to cooperate and restore tissue structure and function. This type of feedback is important because it enables coordination of immune responses and recovery from infections and injuries. During cancer, key elements of this feedback fail. This disrupts tissue function and immunity.<ref>{{cite journal | last1 = Vlahopoulos | first1 = SA | title = Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode. | journal = Cancer Biology & Medicine | date = August 2017 | pmid = 28884042 | doi = 10.20892/j.issn.2095-3941.2017.0029 | volume = 14 | issue = 3 | pages = 254–270 | pmc = 5570602}}</ref><ref>{{cite journal|last1=Korneev|first1=KV|last2=Atretkhany|first2=KN|last3=Drutskaya|first3=MS|last4=Grivennikov|first4=SI|last5=Kuprash|first5=DV|last6=Nedospasov|first6=SA|title=TLR-signaling and proinflammatory cytokines as drivers of tumorigenesis.|journal=Cytokine|date=January 2017|volume=89|pages=127–135|doi=10.1016/j.cyto.2016.01.021|pmid=26854213}}</ref>

Mechanisms of feedback were first elucidated in bacteria, where a nutrient elicits changes in some of their metabolic functions.<ref>{{cite journal|last1= Sanwal|first1=BD| title= Allosteric controls of amphilbolic pathways in bacteria.|journal= Bacteriol. Rev.|date=March 1970|volume=34|issue=1|pages=20–39 |pmid=4315011 |pmc=378347|doi=10.1128/MMBR.34.1.20-39.1970}}</ref>
Feedback is also central to the operations of [[gene]]s and [[gene regulatory network]]s. [[Repressor protein|Repressor]] (see [[Lac repressor]]) and [[activator protein|activator]] [[protein]]s are used to create genetic [[operon]]s, which were identified by [[François Jacob]] and [[Jacques Monod]] in 1961 as ''feedback loops''.<ref>{{cite journal|last1= Jacob|first1=F|last2=Monod|first2=J|title= Genetic regulatory mechanisms in the synthesis of proteins.|journal= J Mol Biol|date=June 1961|volume=3|issue=3|pages=318–356 |pmid=13718526|doi=10.1016/S0022-2836(61)80072-7|s2cid=19804795}}</ref> These feedback loops may be positive (as in the case of the coupling between a sugar molecule and the proteins that import sugar into a bacterial cell), or negative (as is often the case in [[metabolic]] consumption).

On a larger scale, feedback can have a stabilizing effect on animal populations even when profoundly affected by external changes, although time lags in feedback response can give rise to [[Lotka–Volterra equation|predator-prey cycles]].<ref>
CS Holling. "Resilience and stability of ecological systems". Annual Review of Ecology and Systematics 4:1-23. 1973</ref>

In [[zymology]], feedback serves as regulation of activity of an enzyme by its direct {{Not a typo|product(s)}} or downstream {{Not a typo|metabolite(s)}} in the metabolic pathway (see [[Allosteric regulation]]).

The [[hypothalamic–pituitary–adrenal axis]] is largely controlled by positive and negative feedback, much of which is still unknown.

In [[psychology]], the body receives a stimulus from the environment or internally that causes the release of [[hormone]]s. Release of hormones then may cause more of those hormones to be released, causing a positive feedback loop. This cycle is also found in certain behaviour. For example, "shame loops" occur in people who blush easily. When they realize that they are blushing, they become even more embarrassed, which leads to further blushing, and so on.<ref>{{cite magazine|last=Scheff |first=Thomas |url=http://www.psychologytoday.com/blog/lets-connect/200909/the-emotionalrelational-world |title=The Emotional/Relational World |magazine=Psychology Today |date=2009-09-02 |access-date=2013-07-10}}</ref>