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====Chemotaxis-related migratory responses==== [[Image:Chtxphenomen1.png|right|400 px|<div style="text-align: center;border:none">Chemotaxis related migratory responses</div>]] Chemotaxis refers to the directional migration of cells in response to chemical gradients; several variations of chemical-induced migration exist as listed below. * ''[[Chemokinesis]]'' refers to an increase in cellular motility in response to chemicals in the surrounding environment. Unlike chemotaxis, the migration stimulated by chemokinesis lacks directionality, and instead increases environmental scanning behaviors.<ref>{{cite journal | vauthors = Becker EL | title = Stimulated neutrophil locomotion: chemokinesis and chemotaxis | journal = Archives of Pathology & Laboratory Medicine | volume = 101 | issue = 10 | pages = 509β13 | date = October 1977 | pmid = 199132 }}</ref> * In ''[[haptotaxis]]'' the [[gradient]] of the chemoattractant is expressed or bound on a surface, in contrast to the classical model of chemotaxis, in which the gradient develops in a soluble fluid.<ref name="pmid6030602">{{cite journal | vauthors = Carter SB | s2cid = 4212997 | title = Haptotaxis and the mechanism of cell motility | journal = Nature | volume = 213 | issue = 5073 | pages = 256β60 | date = January 1967 | pmid = 6030602 | doi = 10.1038/213256a0 | bibcode = 1967Natur.213..256C }}</ref> The most common biologically active haptotactic surface is the [[extracellular matrix]] (ECM); the presence of bound [[ligands]] is responsible for induction of transendothelial migration and [[angiogenesis]]. * ''[[Necrotaxis]]'' embodies a special type of chemotaxis when the chemoattractant molecules are released from [[necrosis|necrotic]] or [[apoptosis|apoptotic]] cells. Depending on the chemical character of released substances, necrotaxis can accumulate or repel cells, which underlines the pathophysiological significance of this phenomenon.
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