Editing Cell nucleus (section)

====PML-nuclear bodies====
[[Promyelocytic leukemia protein]] (PML-nuclear bodies) are spherical bodies found scattered throughout the nucleoplasm, measuring around 0.1–1.0&nbsp;μm. They are known by a number of other names, including nuclear domain 10 (ND10), Kremer bodies, and PML oncogenic domains.<ref name="Zimber">{{cite journal | vauthors = Zimber A, Nguyen QD, Gespach C | title = Nuclear bodies and compartments: functional roles and cellular signalling in health and disease | journal = Cellular Signalling | volume = 16 | issue = 10 | pages = 1085–104 | date = October 2004 | pmid = 15240004 | doi = 10.1016/j.cellsig.2004.03.020 | department = Review }}</ref> PML-nuclear bodies are named after one of their major components, the promyelocytic leukemia protein (PML). They are often seen in the nucleus in association with Cajal bodies and cleavage bodies.<ref name="Dundr"/> Pml-/- mice, which are unable to create PML-nuclear bodies, develop normally without obvious ill effects, showing that PML-nuclear bodies are not required for most essential biological processes.<ref name="Lallemand2010">{{cite journal | vauthors = Lallemand-Breitenbach V, de Thé H | title = PML nuclear bodies | journal = Cold Spring Harbor Perspectives in Biology | volume = 2 | issue = 5 | pages = a000661 | date = May 2010 | pmid = 20452955 | pmc = 2857171 | doi = 10.1101/cshperspect.a000661 | department = Review }}</ref>